Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications.

@article{Adelnia2021PolyasparticAI,
  title={Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications.},
  author={Hossein Adelnia and Huong D. N. Tran and Peter J. Little and Idriss Blakey and Hang Thu Ta},
  journal={ACS biomaterials science \& engineering},
  year={2021}
}
Poly(aspartic acid) (PASP) is an anionic polypeptide that is a highly versatile, biocompatible, and biodegradable polymer that fulfils key requirements for use in a wide variety of biomedical applications. The derivatives of PASP can be readily tailored via the amine-reactive precursor, poly(succinimide) (PSI), which opens up a large window of opportunity for the design and development of novel biomaterials. PASP also has a strong affinity with calcium ions, resulting in complexation, which has… Expand
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References

SHOWING 1-10 OF 195 REFERENCES
Hydrogels Based on Poly(aspartic acid): Synthesis and Applications
This review presents an overview on the recent progress in the synthesis, crosslinking, interpenetrating networks, and applications of poly(aspartic acid) (PASP)-based hydrogels. PASP is a syntheticExpand
Preparation of γ-aminopropyltriethoxysilane cross-linked poly(aspartic acid) superabsorbent hydrogels without organic solvent
TLDR
A one-step synthesis of PASP resin was introduced, in which the organic phase was replaced by distilled water and γ-aminopropyltriethoxysilane was used as the cross-linker and showed the hydrogel has body-friendly properties. Expand
Emerging biomedical applications of polyaspartic acid-derived biodegradable polyelectrolytes and polyelectrolyte complexes.
TLDR
This mini-review highlights some recent literature examples of unique biomedical applications of PELs, PECs and PEMs prepared through the molecular engineering of PASA, and discusses biomineralization modulators, anti-mycobacterial agents, underwater adhesives, mucoadhesive drug and gene delivery agents, and cell encapsulants fabricated using P ASA derived PELS. Expand
Biodegradation of poly(aspartic acid-lysine) copolymers by mixed bacteria from natural water
Abstract Poly(aspartic acid-lysine) copolymers (PAL), as an alternative product to traditional water treatment agents, was developed based on poly(aspartic acid) through microwave-assisted synthesisExpand
Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery
TLDR
PASP cross-linked with cystamine and lysine-methylester was introduced as fully amino acid-based polymer hydrogel and resulted in an increased drug release due to the cleavage of disulfide bridges in the hydrogels. Expand
Biodegradation and Osteosarcoma Cell Cultivation on Poly(aspartic acid) Based Hydrogels.
TLDR
Thiolated poly(aspartic acid) based hydrogels provide ideal conditions for adhesion, survival, proliferation, and migration of osteoblast-like cells, and the highest viability was found on the thiolated PASP gels while the RGD motif had influence on compacted cluster formation of the cells. Expand
Polysuccinimide and its derivatives: Degradable and water soluble polymers (review)
Abstract Interest for water soluble polymers which show biocompatibility and degradability is growing due to their potential applications in medical sciences. Polysuccinimide (PSI), commonlyExpand
Different types of degradable vectors from low-molecular-weight polycation-functionalized poly(aspartic acid) for efficient gene delivery.
TLDR
In comparison with gold standard polyethylenimine (PEI, ∼ 25 kDa), the cationic PAsp-based vectors, particularly star-shaped ones, exhibited much better transfection performances. Expand
An enzyme-mediated in situ hydrogel based on polyaspartamide derivatives for localized drug delivery and 3D scaffolds
An injectable and biodegradable enzymatically crosslinked hydrogel based on poly(α,β-aspartic acid) modified with tyramine (TA) and 3-amino-1-propanol (AP) (PASP-g-TA/AP) was prepared underExpand
Synthesis and swelling properties of novel pH-sensitive poly(aspartic acid) gels.
TLDR
The unidirectional stress-strain behavior of the gels as well as the dependence of equilibrium swelling degree on the pH was carefully studied and the most important network parameters were determined by a modified version of the Brannon-Peppas- Peppas theory. Expand
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