Poly(amidoamine)s as potential nonviral vectors: ability to form interpolyelectrolyte complexes and to mediate transfection in vitro.

@article{Richardson2001PolyamidoaminesAP,
  title={Poly(amidoamine)s as potential nonviral vectors: ability to form interpolyelectrolyte complexes and to mediate transfection in vitro.},
  author={Simon C. W. Richardson and Nicola G. Pattrick and Yan Man and Paolo Ferruti and Ruth Duncan},
  journal={Biomacromolecules},
  year={2001},
  volume={2 3},
  pages={
          1023-8
        }
}
Poly(amidoamine)s (PAAs) are water-soluble polymers that display pH-dependent membrane activity. PAAs have the potential to act as a synthetic alternative to fusogenic peptides and thus promote endosomal escape. The purpose of this study was to investigate for the first time whether PAA have the ability to complex DNA, protect it from nuclease degradation and to promote transfection in vitro. PAAs ISA 1 (Mn 6900) and ISA 23 (Mn 10,500) and their 2-phenylethylamine containing analogues ISA 4 and… Expand
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