Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism.

@article{Mandir1999PolyADPribosePA,
  title={Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism.},
  author={Allen S. Mandir and Serge E. Przedborski and Vernice R. Jackson-Lewis and Zhao Qi Wang and Cynthia Marie Simbulan-Rosenthal and Mark E. Smulson and Brad Hoffman and D B Guastella and Valina L Dawson and Ted M Dawson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 10},
  pages={5774-9}
}
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that causes parkinsonism in humans and nonhuman animals, and its use has led to greater understanding of the pathogenesis of Parkinson's disease. However, its molecular targets have not been defined. We show that mice lacking the gene for poly(ADP-ribose) polymerase (PARP), which catalyzes… CONTINUE READING