Poly(A)(+) mRNA-binding protein Tudor-SN regulates stress granules aggregation dynamics.

@article{Gao2015PolyAMP,
  title={Poly(A)(+) mRNA-binding protein Tudor-SN regulates stress granules aggregation dynamics.},
  author={Xingjie Gao and Xue Hai Fu and Juan Song and Yi Zhang and Xiaoteng Cui and Chao Hao Su and Lin Ge and Jie Shao and Lingbiao Xin and Juha Saarikettu and Mei Xin Mei and Xi Yang and Minxin Wei and Olli Silvennoinen and Zhi Bin Yao and Jinyan He and Jie Yang},
  journal={The FEBS journal},
  year={2015},
  volume={282 5},
  pages={
          874-90
        }
}
  • Xingjie Gao, Xue Hai Fu, +14 authors Jie Yang
  • Published in The FEBS journal 2015
  • Biology, Medicine
  • Stress granules (SGs) and processing bodies (PBs) comprise the main types of cytoplasmic RNA foci during stress. Our previous data indicate that knockdown of human Tudor staphylococcal nuclease (Tudor-SN) affects the aggregation of SGs. However, the precise molecular mechanism has not been determined fully. In the present study, we demonstrate that Tudor-SN binds and colocalizes with many core components of SGs, such as poly(A)(+) mRNA binding protein 1, T-cell internal antigen-1-related… CONTINUE READING

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