Poly(4-Hydroxybutyrate): Current State and Perspectives

@article{Utsunomia2020Poly4HydroxybutyrateCS,
  title={Poly(4-Hydroxybutyrate): Current State and Perspectives},
  author={Camila Utsunomia and Qun Ren and Manfred Zinn},
  journal={Frontiers in Bioengineering and Biotechnology},
  year={2020},
  volume={8}
}
By the end of 1980s, for the first time polyhydroxyalkanoate (PHA) copolymers with incorporated 4-hydroxybutyrate (4HB) units were produced in the bacterium Cupriavidus necator (formally Ralstonia eutropha) from structurally related carbon sources. After that, production of PHA copolymers composed of 3-hydroxybutyrate (3HB) and 4HB [P(3HB-co-4HB)] was demonstrated in diverse wild-type bacteria. The P4HB homopolymer, however, was hardly synthesized because existing bacterial metabolism on 4HB… 

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