Poly(imidazole/DMAEA)phosphazene/DNA self-assembled nanoparticles for gene delivery: synthesis and in vitro transfection.

@article{Yang2008PolyimidazoleDMAEAphosphazeneDNASN,
  title={Poly(imidazole/DMAEA)phosphazene/DNA self-assembled nanoparticles for gene delivery: synthesis and in vitro transfection.},
  author={Yongxin Yang and Zhenghong Xu and Jingui Jiang and Yu Gao and Wangwen Gu and Lingli Chen and Xiaozheng Tang and Yaping Li},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2008},
  volume={127 3},
  pages={273-9}
}
A new cationic derivate of polyphosphazene with imidazole and 2-dimethylaminoethylamino (DMAEA) as side groups, poly(imidazole/DMAEA)phosphazene (PIDP), was synthesized and investigated for gene delivery. The half-lives of PIDP degradation under neutral (pH 7.4) and acidic conditions (pH 5.0) were 22 and 3 days at 37 degrees C, respectively. The… CONTINUE READING