Poly(ethylene imine)s as antimicrobial agents with selective activity.

@article{Gibney2012PolyethyleneIA,
  title={Poly(ethylene imine)s as antimicrobial agents with selective activity.},
  author={Katherine A. Gibney and Iva Sovadinova and Analette Inducil Lopez and Michael Patrick Urban and Zachary Ridgway and Gregory A Caputo and Kenichi Kuroda},
  journal={Macromolecular bioscience},
  year={2012},
  volume={12 9},
  pages={
          1279-89
        }
}
We report the structure-activity relationship in the antimicrobial activity of linear and branched poly(ethylene imine)s (L- and B-PEIs) with a range of molecular weights (MWs) (500-12,000). Both L- and B-PEIs displayed enhanced activity against Staphylococcus aureus over Escherichia coli. Both B- and L-PEIs did not cause any significant permeabilization of E. coli cytoplasmic membrane. L-PEIs induced depolarization of S. aureus membrane although B-PEIs did not. The low MW B-PEIs caused little… CONTINUE READING
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