Poly(ethylene glycol)-conjugated anti-EGF receptor antibody C225 with radiometal chelator attached to the termini of polymer chains.

@article{Wen2001PolyethyleneGA,
  title={Poly(ethylene glycol)-conjugated anti-EGF receptor antibody C225 with radiometal chelator attached to the termini of polymer chains.},
  author={Xiaoxia Wen and Qing Ping Wu and Yan Lu and Zhaoqi Fan and Chusilp Charnsangavej and S Willard Wallace and Diana S. L. Chow and Chun Xing Li},
  journal={Bioconjugate chemistry},
  year={2001},
  volume={12 4},
  pages={
          545-53
        }
}
Several biological barriers, including significant liver uptake, limit the clinical application of radiolabeled antibodies in radioimmunoscintigraphy. Here, a general approach is described for radiolabeling of monoclonal antibodies conjugated with poly(ethylene glycol) (PEG). This strategy is demonstrated with C225, a monoclonal antibody directed against epidermal growth factor (EGF) receptor. We synthesized a heterofunctional PEG with one end attached to a radiometal chelator… CONTINUE READING
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