Poly(ethylene glycol) as stabilizer and emulsifying agent: a novel stabilization approach preventing aggregation and inactivation of proteins upon encapsulation in bioerodible polyester microspheres.

@article{Castellanos2003PolyethyleneGA,
  title={Poly(ethylene glycol) as stabilizer and emulsifying agent: a novel stabilization approach preventing aggregation and inactivation of proteins upon encapsulation in bioerodible polyester microspheres.},
  author={Ingrid J. Castellanos and Rub{\'e}n Gonz{\'a}lez Crespo and Kai Griebenow},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2003},
  volume={88 1},
  pages={135-45}
}
Protein aggregation and inactivation are major problems associated with the encapsulation of pharmaceutical proteins in biodegradable microspheres. The objectives of this study were to identify the causes of aggregation and inactivation of two model enzymes upon solid-in-oil-in-water (s/o/w) encapsulation in poly(lactic-co-glycolic) acid (PLGA) microspheres in order to rationally develop approaches assuring their stability. S/o/w encapsulation of gamma-chymotrypsin in PLGA microspheres caused… CONTINUE READING

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