Poly(ethylene glycol) as a sensitive regulator of cell survival fate on polymeric biomaterials: the interplay of cell adhesion and pro-oxidant signaling mechanisms

@inproceedings{Sung2010PolyethyleneGA,
  title={Poly(ethylene glycol) as a sensitive regulator of cell survival fate on polymeric biomaterials: the interplay of cell adhesion and pro-oxidant signaling mechanisms},
  author={Hak-Joon Sung and Arnold Luk and N. Sanjeeva Murthy and Er Liu and Malasa Jois and Abraham Joy and Jared S Bushman and Prabhas V Moghe and Joachim Kohn},
  year={2010}
}
  • Hak-Joon Sung, Arnold Luk, +6 authors Joachim Kohn
  • Published 2010
  • Chemistry
  • Poly(ethylene glycol) (PEG) is one of the most widely used compounds across a variety of platforms and is increasingly found in medical applications. Polycarbonates containing varying mol% of PEG (Mw 1000) were used to probe the effects of PEG on cell adhesion, proliferation, spreading, and survival. Two contrasting PEG-mediated cell signaling elements affected these cellular behaviors: (i) integrin α5 receptor mediated cellular focal adhesions to the biomaterial surface and (ii) modulation of… CONTINUE READING

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