Poly(ethylene oxide)-block-polyphosphoester-graft-paclitaxel conjugates with acid-labile linkages as a pH-sensitive and functional nanoscopic platform for paclitaxel delivery.

@article{Zou2014PolyethyleneOC,
  title={Poly(ethylene oxide)-block-polyphosphoester-graft-paclitaxel conjugates with acid-labile linkages as a pH-sensitive and functional nanoscopic platform for paclitaxel delivery.},
  author={Jiong Zou and Fuwu Zhang and Shiyi Zhang and Stephanie F Pollack and Mahmoud Elsabahy and Jingwei Fan and Karen L Wooley},
  journal={Advanced healthcare materials},
  year={2014},
  volume={3 3},
  pages={
          441-8
        }
}

• Jiong Zou, Fuwu Zhang, +4 authors Karen L Wooley
• Published in Advanced healthcare materials 2014
• DOI:10.1002/adhm.201300235

There has been an increasing interest to develop new types of stimuli-responsive drug delivery vehicles with high drug loading and controlled release properties for chemotherapeutics. An acid-labile poly(ethylene oxide)-block-polyphosphoester-graft-PTX drug conjugate (PEO-b-PPE-g-PTX G2) degradable, polymeric paclitaxel (PTX) conjugate containing ultra-high levels of PTX loading is improved significantly, in this second-generation development, which involves connection of each PTX molecule to… CONTINUE READING

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