Poly(etheno ADP-ribose) blocks poly(ADP-ribose) glycohydrolase activity.

  title={Poly(etheno ADP-ribose) blocks poly(ADP-ribose) glycohydrolase activity.},
  author={Masayasu Shirato and Shunichi Tozawa and Daisuke Maeda and Masatoshi Watanabe and Hitoshi Nakagama and Mitsuko Masutani},
  journal={Biochemical and biophysical research communications},
  volume={355 2},
Poly(ADP-ribose) is a biopolymer synthesized by poly(ADP-ribose) polymerases. Recent findings suggest the possibility for modulation of cellular functions including cell death and mitosis by poly(ADP-ribose). Derivatization of poly(ADP-ribose) may be useful for investigating the effects of poly(ADP-ribose) on various cellular processes. We prepared poly(etheno ADP-ribose) (poly(epsilonADP-ribose)) by converting the adenine moiety of poly(ADP-ribose) to 1-N(6)-etheno adenine residues. Poly… CONTINUE READING