Poly(epsilon-caprolactone) and poly (L-lactic-co-glycolic acid) degradable polymer sponges attenuate astrocyte response and lesion growth in acute traumatic brain injury.

@article{Wong2007PolyepsiloncaprolactoneAP,
  title={Poly(epsilon-caprolactone) and poly (L-lactic-co-glycolic acid) degradable polymer sponges attenuate astrocyte response and lesion growth in acute traumatic brain injury.},
  author={Darice Yukfun Wong and Scott J. Hollister and Paul H Krebsbach and Christopher A. Nosrat},
  journal={Tissue engineering},
  year={2007},
  volume={13 10},
  pages={
          2515-23
        }
}
This study evaluated the response of rat brain to 2 degradable polymers (poly (L-lactic-co-glycolic acid) (PLGA), and poly(epsilon-caprolactone) (PCL)), two common materials in tissue engineering. PLGA has been extensively studied in the brain for controlled drug release as injectable microspheres and is generally accepted as biocompatible in that capacity. Biocompatibility in other forms and for different functions in the brain has not been widely studied. PCL was chosen as an alternative to… CONTINUE READING

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