Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin.

Abstract

Biodegradable polymers have emerged as highly effective drug delivery vehicles. We combine N-carboxyanhydride and O-carboxyanhydride ring opening polymerisations to synthesise a poly(amino acid)-polyester graft copolymer capable of encapsulating, and subsequently releasing doxorubicin via acid-mediated hydrolysis. Consequently, the nanoparticles detailed… (More)
DOI: 10.1039/c7cc04504b

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