Poly(L-lysine)-GRGDS as a biomimetic surface modifier for poly(lactic acid).

@article{Quirk2001PolyLlysineGRGDSAA,
  title={Poly(L-lysine)-GRGDS as a biomimetic surface modifier for poly(lactic acid).},
  author={Robin A. Quirk and Weng Chen Chan and Martyn Davies and Saul J. B. Tendler and Kevin M. Shakesheff},
  journal={Biomaterials},
  year={2001},
  volume={22 8},
  pages={865-72}
}
The immobilization of adhesion peptide sequences (such as RGD) at the surfaces of poly(alpha-hydroxyacid)s, including poly(lactic acid) (PLA), is complicated by an absence of functional groups to support covalent attachment. We demonstrate a method to overcome this problem, by attaching the peptide to poly(L-lysine) (PLL), which immobilizes the sequence through adsorption at the poly(alpha-hydroxyacid) surface. When coated using a 0.01% w/v solution of PLL-GRGDS, bovine aortic endothelial cells… CONTINUE READING