Poly(ADP-ribosyl)ation in mammalian ageing

  title={Poly(ADP-ribosyl)ation in mammalian ageing},
  author={Sascha Beneke and Alexander B{\"u}rkle},
  booktitle={Nucleic acids research},
Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through… CONTINUE READING