Poly(ADP-ribose)polymerase-1 is required for integration of the human immunodeficiency virus type 1 genome near centromeric alphoid DNA in human and murine cells.

@article{Kameoka2005PolyADPribosepolymerase1IR,
  title={Poly(ADP-ribose)polymerase-1 is required for integration of the human immunodeficiency virus type 1 genome near centromeric alphoid DNA in human and murine cells.},
  author={Masanori Kameoka and Souichi Nukuzuma and Asako Itaya and Yasuharu Tanaka and Katsuya Ota and Yoshiaki Inada and Kazuyoshi Ikuta and Koichiro Yoshihara},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={334 2},
  pages={412-7}
}
This study examined the efficiency of human immunodeficiency virus type 1 (HIV-1) integration in poly(ADP-ribose)polymerase-1 (PARP-1)-deficient murine cells and in human cell lines transfected with small interfering RNA against PARP-1 (PARP-1 siRNA). To semi-quantify the amount of integrated HIV-1 genome, real-time nested PCR was carried out using primers specific for Alu and alphoid DNA combined with primers for the HIV-1 genome. The results showed that the integration efficiency of the HIV-1… CONTINUE READING
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