Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.

@article{MeyerFicca2011PolyADPribosePP,
  title={Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.},
  author={Mirella L. Meyer-Ficca and Julia D. Lonchar and Motomasa Ihara and Marvin L. Meistrich and Caroline Ann Austin and Ralph G. Meyer},
  journal={Biology of reproduction},
  year={2011},
  volume={84 5},
  pages={900-9}
}
To achieve the specialized nuclear structure in sperm necessary for fertilization, dramatic chromatin reorganization steps in developing spermatids are required where histones are largely replaced first by transition proteins and then by protamines. This entails the transient formation of DNA strand breaks to allow for, first, DNA relaxation and then chromatin compaction. However, the nature and origin of these breaks are not well understood. We previously reported that these DNA strand breaks… CONTINUE READING
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