Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited.

  title={Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited.},
  author={Alberto Chiarugi},
  journal={Trends in pharmacological sciences},
  volume={23 3},
Poly(ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear enzyme involved in DNA repair. The therapeutic efficacy of drugs that inhibit PARP-1 in various disorders underscores the active role of PARP-1 in cell death. Although it is well established that excessive DNA damage causes PARP-1 hyperactivation, which leads to cell death by energy failure, a new mechanistic perspective is emerging following the identification of various PARPs that exhibit different features and subcellular… CONTINUE READING