Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis.

@article{MeyerFicca2011PolyADPriboseMI,
  title={Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis.},
  author={Mirella L. Meyer-Ficca and Motomasa Ihara and Julia D. Lonchar and Marvin L. Meistrich and Caroline Ann Austin and Wookee Min and Z Wang and Ralph G. Meyer},
  journal={Biology of reproduction},
  year={2011},
  volume={84 2},
  pages={218-28}
}
Sperm chromatin is organized in a protamine-based, highly condensed form, which protects the paternal chromosome complement in transit, facilitates fertilization, and supports correct gene expression in the early embryo. Very few histones remain selectively associated with genes and defined regulatory sequences essential to embryonic development, while most of the genome becomes bound to protamine during spermiogenesis. Chromatin remodeling processes resulting in the dramatically different… CONTINUE READING