Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells

@inproceedings{Ishikawa2017PolyAspecificRR,
  title={Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells},
  author={Hideaki Muroishi Ishikawa and Harunori Yoshikawa and Keiichi Izumikawa and Yutaka Miura and Masato Taoka and Yuko Nobe and Yoshio Yamauchi and Hiroshi Nakayama and Richard J. Simpson and Toshiaki Isobe and N. Shinichi Takahashi},
  booktitle={Nucleic acids research},
  year={2017}
}
Ribosome biogenesis occurs successively in the nucleolus, nucleoplasm, and cytoplasm. Maturation of the ribosomal small subunit is completed in the cytoplasm by incorporation of a particular class of ribosomal proteins and final cleavage of 18S-E pre-rRNA (18S-E). Here, we show that poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S-E maturation in human cells. We found PARN as a novel component of the pre-40S particle pulled down with the pre-ribosome factor LTV1 or… CONTINUE READING

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