Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA.

@article{Onesto2004PolyAbindingPP,
  title={Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA.},
  author={Cercina Onesto and Edurne Berra and Renaud Gr{\'e}pin and Gilles Pag{\'e}s},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 33},
  pages={34217-26}
}
Expression of vascular endothelial growth factor (VEGF) is tightly regulated, particularly at the level of its mRNA stability, which is essentially mediated through the 3'-untranslated region (3'-UTR) of VEGF mRNA. To identify new protein partners regulating VEGF mRNA stability, we screened a cDNA expression library with an RNA probe corresponding to the entire VEGF mRNA 3'-UTR. We identified the "poly(A)-binding protein-interacting protein 2" (PAIP2) as a new VEGF mRNA 3'-UTR interacting… CONTINUE READING

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