Poly(A)-binding protein 1 partially relocalizes to the nucleus during herpes simplex virus type 1 infection in an ICP27-independent manner and does not inhibit virus replication.

@article{Salaun2010PolyAbindingP1,
  title={Poly(A)-binding protein 1 partially relocalizes to the nucleus during herpes simplex virus type 1 infection in an ICP27-independent manner and does not inhibit virus replication.},
  author={C Salaun and A I MacDonald and Osmany Larralde and L Howard and K Lochtie and Hannah Burgess and M Brook and P Malik and N K Gray and Sheila V Graham},
  journal={Journal of virology},
  year={2010},
  volume={84 17},
  pages={8539-48}
}
Infection of cells by herpes simplex virus type 1 (HSV-1) triggers host cell shutoff whereby mRNAs are degraded and cellular protein synthesis is diminished. However, virus protein translation continues because the translational apparatus in HSV-infected cells is maintained in an active state. Surprisingly, poly(A)-binding protein 1 (PABP1), a predominantly cytoplasmic protein that is required for efficient translation initiation, is partially relocated to the nucleus during HSV-1 infection… CONTINUE READING

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