Poly(A), poly(A) binding protein and the regulation of mRNA stability.

@article{Bernstein1989PolyAPB,
  title={Poly(A), poly(A) binding protein and the regulation of mRNA stability.},
  author={Paul R. Bernstein and Jeffrey R. Ross},
  journal={Trends in biochemical sciences},
  year={1989},
  volume={14 9},
  pages={
          373-7
        }
}
This review has focused on the possibility that interactions between mRNA sequences and the poly(A)-nucleoprotein complex play important roles in mRNA turnover. It is important to stress that additional genetic and biochemical tests are necessary to characterize how PABP interacts with mRNA in cells and to determine whether the poly(A) protection hypothesis is accurate. Moreover, there may be a significant number of mRNAs whose half-lives are independent of polyadenylation. For example, the… CONTINUE READING

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