Poloxamine-based nanomaterials for drug delivery.

  title={Poloxamine-based nanomaterials for drug delivery.},
  author={Carmen Alvarez‐Lorenzo and Ana Rey-Rico and Alejandro Sosnik and Pablo Taboada and Angel Concheiro},
  journal={Frontiers in bioscience},
Poloxamines (Tetronic) are X-shaped amphiphilic block copolymers formed by four arms of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) blocks bonded to a central ethylenediamine moiety. Such a structure confers multi-responsive behaviour, namely temperature and pH-sensitiveness. At relatively low concentrations but above the critical micellar concentration (CMC), poloxamines generate polymeric micelles. Due to the presence of a hydrophobic core, these nanocarriers are useful in the… 

PEO-PPO block copolymers for passive micellar targeting and overcoming multidrug resistance in cancer therapy.

Clinical trials in progress indicate that drug-loaded polymeric micelles are beneficial regarding efficiency, safety, and compliance of the treatment and quality of life of the patients.

NaCl-triggered self-assembly of hydrophilic poloxamine block copolymers.

Nanocomposite gels of poloxamine and Laponite for β-Lapachone release in anticancer therapy.

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Findings together with promising hen's egg test-chorioallantoic membrane biocompatibility tests make poloxamine micelles promising nanocarriers for carbonic anhydrase inhibitors in the treatment of glaucoma.

Supramolecular cyclodextrin-based drug nanocarriers.

An overall view of the diversity of designs of CD-based supramolecular nanosystems with a special focus on the advances materialized in the last five years, including clinical trials is provided.

Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer

Several aspects of poloxamines and poloxamers concerning their general properties and their applications in drug and gene delivery are reviewed, including the preparation and characterization techniques of polymeric micelles with a focus in micelleplexes which can be used as a simultaneous drug and nucleic acid carrier.

Poloxamer Hydrogels for Biomedical Applications

The use of poloxamers as biosurfactants is evaluated since they are able to form micelles in an aqueous environment above a concentration threshold known as critical micelle concentration (CMC), which is exploited for drug delivery and different therapeutic applications.

New Advances in Biomedical Application of Polymeric Micelles

This review is a compilation of updated therapeutic applications of PMs, such as PMs that are based on Pluronics®, micelleplexes and Pox-based PMs in several biomedical applications.



Amphiphilic block copolymers for drug delivery.

The purpose of this minireview is to provide a concise, yet detailed, introduction to the use of ABCs and polymeric micelles as delivery agents as well as to highlight current and past work in this area.

Block copolymer micelles: preparation, characterization and application in drug delivery.

Micellar Nanocarriers: Pharmaceutical Perspectives

This review will discuss some recent trends in using micelles as pharmaceutical carriers, including lipid-core micells, which may become the imaging agents of choice in different imaging modalities.

Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery.

This review focuses on recent developments concerning stimuli- responsive polymersomes made of amphiphilic block copolymers and their potential applications within the biomedical field.

Structure and design of polymeric surfactant-based drug delivery systems.

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Novel pH sensitive block copolymer micelles for solvent free drug loading.

The present results suggest that the pH induced micellization method due to the micelle-unimer transition of the pH sensitive block copolymer would be a novel and valuable drug incorporation tool for hydrophobic and protein drugs, since no organic solvent is involved in the formulation.

Development of acid-sensitive copolymer micelles for drug delivery

The development of micellar carriers capable of releasing their drug load in response to small changes in pH by incorporating “titratable” groups such as amines and carboxylic acids into the copolymer backbone, thus altering the solubility of the polymer upon protonation and disrupting micelle formation is studied.

Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery

PLGA nanoparticles in drug delivery: the state of the art.

The crux of the problem is the stability of nanoparticles after preparation, which is being addressed by freeze-drying using different classes of lyoprotectants.

Novel pH-sensitive supramolecular assemblies for oral delivery of poorly water soluble drugs: preparation and characterization.