Poloxamer 188 protects against ischemia-reperfusion injury in a murine hind-limb model.

@article{Murphy2010Poloxamer1P,
  title={Poloxamer 188 protects against ischemia-reperfusion injury in a murine hind-limb model.},
  author={Adrian D Murphy and Michael C. McCormack and David A. Bichara and John T. Nguyen and Mark A. Randolph and Michael T. Watkins and Raphael C. Lee and William Gerald Austen},
  journal={Plastic and reconstructive surgery},
  year={2010},
  volume={125 6},
  pages={1651-60}
}
BACKGROUND Ischemia-reperfusion injury can activate pathways generating reactive oxygen species, which can injure cells by creating holes in the cell membranes. Copolymer surfactants such as poloxamer 188 are capable of sealing defects in cell membranes. The authors postulated that a single-dose administration of poloxamer 188 would decrease skeletal myocyte injury and mortality following ischemia-reperfusion injury. METHODS Mice underwent normothermic hind-limb ischemia for 2 hours. Animals… CONTINUE READING

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