Polo-like kinase is a cell cycle-regulated kinase activated during mitosis.

@article{Hamanaka1995PololikeKI,
  title={Polo-like kinase is a cell cycle-regulated kinase activated during mitosis.},
  author={Ryoji Hamanaka and Mark R. Smith and Patrick M. O'Connor and Sharon C Maloid and Kelly Mihalic and Jerry L. Spivak and Dan L. Longo and Douglas K. Ferris},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 36},
  pages={
          21086-91
        }
}
Previously, we demonstrated that expression of polo-like kinase (PLK) is required for cellular DNA synthesis and that overexpression of PLK is sufficient to induce DNA synthesis. We now report that the endogenous levels of PLK, its phosphorylation status, and protein kinase activity are tightly regulated during cell cycle progression. PLK protein is low in G1, accumulates during S and G2M, and is rapidly reduced after mitosis. During mitosis, PLK is phosphorylated on serine, and its serine… CONTINUE READING
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