Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway

@inproceedings{Tian2017PololikeK4,
  title={Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway},
  author={Xiangdong Tian and Dejun Zhou and Lu Chen and Yao Tian and Benfu Zhong and Yanna Cao and Qiuping Dong and Meng Zhou and Jie Yan and Yalei Wang and Yanli Qiu and Lianmin Zhang and Zhongyuan Li and Huijuan Wang and Daowei Wang and Guoguang Ying and Qiang Zhao},
  booktitle={Cell Death & Disease},
  year={2017}
}
  • Xiangdong Tian, Dejun Zhou, +14 authors Qiang Zhao
  • Published in Cell Death & Disease 2017
  • Medicine, Biology
  • Neuroblastoma (NB) is the most common malignant tumor in infancy and most common extracranial solid tumor in childhood. With the improvement of diagnosis and treatment, the survival rate of patients with low-risk and intermediate-risk NB can reach up to 90%. In contrast, for high-risk NBs, the long-term survival rate is still <40% because of heterogeneity of this tumor. The pathogenesis of NB is still not explicit, therefore it is of great significance to explore the mechanism of NB… CONTINUE READING

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