Polo-like kinase 4: the odd one out of the family

@inproceedings{Sillibourne2010PololikeK4,
  title={Polo-like kinase 4: the odd one out of the family},
  author={James E. Sillibourne and Michel Bornens},
  booktitle={Cell Division},
  year={2010}
}
Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication. The turn-over of this kinase must be strictly controlled to prevent centriole amplification. This is achieved, in part, by an autoregulatory mechanism, whereby PLK4 autophosphorylates residues in a PEST sequence located carboxy-terminal to its catalytic domain. Phosphorylated PLK4 is subsequently recognized by the SCF… CONTINUE READING

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