Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.

@article{Yang2008PololikeK3,
  title={Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.},
  author={Yali Yang and Jingxiang Bai and Rulong Shen and Sharron A. N. Brown and Elena Komissarova and Ying Huang and Ning Jiang and Gregory F. Alberts and Max Costa and Luo Lu and Jeffrey A Winkles and Wei Dai},
  journal={Cancer research},
  year={2008},
  volume={68 11},
  pages={4077-85}
}
Polo-like kinase 3 (Plk3) is an important mediator of the cellular responses to genotoxic stresses. In this study, we examined the physiologic function of Plk3 by generating Plk3-deficient mice. Plk3(-/-) mice displayed an increase in weight and developed tumors in various organs at advanced age. Many tumors in Plk3(-/-) mice were large in size, exhibiting enhanced angiogenesis. Plk3(-/-) mouse embryonic fibroblasts were hypersensitive to the induction of hypoxia-inducible factor-1 alpha (HIF-1… CONTINUE READING