Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis

Abstract

High polo-like kinase 1 (PLK1) expression has been linked to poor outcome in neuroblastoma (NB), indicating that it represents a relevant therapeutic target in this malignancy. Here, we identify a synergistic induction of apoptosis by the PLK1 inhibitor BI 2536 and vinca alkaloids in NB cells. Synergistic drug interaction of BI 2536 together with… (More)
DOI: 10.18632/oncotarget.3901

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@inproceedings{Czaplinski2016PololikeK1, title={Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis}, author={Sebastian Czaplinski and Manuela Hugle and Valerie Stiehl and Simone Fulda}, booktitle={Oncotarget}, year={2016} }