Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.

@article{Lee2012PololikeK1,
  title={Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.},
  author={Cathy Lee and Abbas Fotovati and Joanna Triscott and James Chen and C Nimita Venugopal and Ash Singhal and Christopher Dunham and J. M. Munro Kerr and Mait{\'e} Verreault and S. W. L. Yip and Hiroaki Wakimoto and Chris K Jones and Aarthi A Jayanthan and Aru Narendran and Sheila K Singh and Sandra E. Dunn},
  journal={Stem cells},
  year={2012},
  volume={30 6},
  pages={1064-75}
}
Glioblastoma multiforme (GBM) ranks among the deadliest types of cancer and given these new therapies are urgently needed. To identify molecular targets, we queried a microarray profiling 467 human GBMs and discovered that polo-like kinase 1 (PLK1) was highly expressed in these tumors and that it clustered with the proliferative subtype. Patients with PLK1-high tumors were more likely to die from their disease suggesting that current therapies are inactive against such tumors. This prompted us… CONTINUE READING
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