Polo-like kinase 1: target and regulator of transcriptional control.

@article{Martin2006PololikeK1,
  title={Polo-like kinase 1: target and regulator of transcriptional control.},
  author={Bernd T Martin and Klaus I Strebhardt},
  journal={Cell cycle},
  year={2006},
  volume={5 24},
  pages={2881-5}
}
Deregulated cell cycle control is a hallmark of cancer cells. Developmental or other mitogenic stimuli activate the proliferation of normal cells in response to the requirements of growing tissues. In contrast, cancer cells liberate from proliferative restrictions exerted by anti-proliferative signals arising from the stroma and by endogenous genetic programs that correlate to the terminal differentiation of cells. The study of cyclin-dependent kinases (Cdks) and polo-like kinases (Plks) as… CONTINUE READING