Polo-like Kinase 1 (Plk1) Up-regulates Telomerase Activity by Affecting Human Telomerase Reverse Transcriptase (hTERT) Stability.

@article{Huang2015PololikeK1,
  title={Polo-like Kinase 1 (Plk1) Up-regulates Telomerase Activity by Affecting Human Telomerase Reverse Transcriptase (hTERT) Stability.},
  author={Yan Huang and Liping Sun and Ningning Liu and Qian Wei and Liangzhen Jiang and Xiaomei Tong and Xin Ye},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 30},
  pages={18865-73}
}
Maintenance of telomere is regulated by active telomerase complex, including telomerase holoenzyme and its associated proteins. The activity of telomerase is precisely controlled in cells, and its dysregulation is one of the hallmarks of cancer. The telomerase catalytic subunit human telomerase reverse transcriptase (hTERT) plays a central role for telomerase activity. In this study, we indentified that Polo-like kinase 1 (Plk1) is a novel telomerase-associated protein. Plk1 can interact with… CONTINUE READING
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