Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity.

@article{StPierre2009PoloKR,
  title={Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity.},
  author={Julie St-Pierre and M{\'e}lanie Douziech and Franck Bazile and Mirela Pascariu and {\'E}ric Bonneil and V{\'e}ronique Sauv{\'e} and Hery Ratsima and Damien D'Amours},
  journal={Molecular cell},
  year={2009},
  volume={34 4},
  pages={416-26}
}
A defining feature of mitosis is the reorganization of chromosomes into highly condensed structures capable of withstanding separation and large-scale intracellular movements. This reorganization is promoted by condensin, an evolutionarily conserved multisubunit ATPase. Here we show, using budding yeast, that condensin is regulated by phosphorylation specifically in anaphase. This phosphorylation depends on several mitotic regulators, and the ultimate effector is the Polo kinase Cdc5. We… CONTINUE READING