Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles

@article{Glover2005PoloKA,
  title={Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles},
  author={David M Glover},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={230-237}
}
Genes for the mitotic kinases Polo and Aurora A were first identified in Drosophila through screens of maternal effect lethal mutations for defects in spindle pole behaviour. These enzymes have been shown to be highly conserved and required for multiple functions in mitosis. Polo is stabilized at the centrosome by association with Hsp90. It is required for centrosome maturation on M-phase entry in order to recruit the γ-tubulin ring complex and activate the abnormal spindle protein, Asp. These… CONTINUE READING
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