Polo-box domain: a versatile mediator of polo-like kinase function

  title={Polo-box domain: a versatile mediator of polo-like kinase function},
  author={Jung-Eun · Lee Park and Nak-Kyun Soung and Yoshikazu Johmura and Young Hwi Kang and Chenzhong Liao and Kyung ho Lee and Chi Hoon Park and Marc C. Nicklaus and Kyung Sun Lee},
  journal={Cellular and Molecular Life Sciences},
Members of the polo subfamily of protein kinases have emerged as important regulators in diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests that a highly conserved polo-box domain (PBD) present in the C-terminal non-catalytic region of polo kinases plays a pivotal role in the function of these enzymes. Recent advances in our comprehension of the mechanisms underlying mammalian polo-like kinase 1 (Plk1)-dependent protein–protein interactions revealed that… CONTINUE READING
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