Pollen proteolytic enzymes degrade tight junctions.

  title={Pollen proteolytic enzymes degrade tight junctions.},
  author={Sarah K. Runswick and Thomas Mitchell and Paul Sheldon Davies and Clive Robinson and David R. Garrod},
  volume={12 6},
BACKGROUND AND OBJECTIVE Asthma and allergic rhinitis are significant, increasing causes of morbidity worldwide. Pollen, a major cause of seasonal rhinitis/conjunctivitis, carries proteolytic enzymes on its surface. We showed previously that peptidase allergens from house dust mites compromise epithelial barrier function by degrading the extracellular domains of the tight junction proteins, occludin and claudin, thus facilitating allergen delivery across epithelial layers. In this study, we… CONTINUE READING
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