Poliovirus-specific intestinal antibody responses coincide with decline of poliovirus excretion.


Antibody responses to poliovirus type 3 were studied in fecal samples of 66 children immunized with 3 doses of enhanced-potency inactivated poliovirus vaccine (E-IPV), followed by 1 dose of monovalent oral poliovirus vaccine (OPV, type 3 Sabin). One fecal sample taken before OPV vaccination and 9 collected thereafter were tested for neutralizing antibodies by a microneutralization assay and for class-specific responses by heavy chain-capture radioimmunoassays. Both neutralizing antibody and IgA responses usually occurred during the second week and coincided with ceasing of virus excretion or a decrease in the excreted virus titer. Half of the vaccinees had received a trypsin-modified E-IPV, but their responses did not differ from those of children immunized with the regular E-IPV. These results are in agreement with the view that an intestinal antibody response, mainly consisting of IgA, may be involved in the ceasing of a primary poliovirus excretion.

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@article{Valtanen2000PoliovirusspecificIA, title={Poliovirus-specific intestinal antibody responses coincide with decline of poliovirus excretion.}, author={S Valtanen and Merja M Roivainen and Laura Piirainen and Mirja Stenvik and Tapani Hovi}, journal={The Journal of infectious diseases}, year={2000}, volume={182 1}, pages={1-5} }