Poliovirus proves IRES-istible in vivo.

  title={Poliovirus proves IRES-istible in vivo.},
  author={Bert L Semler},
  journal={The Journal of clinical investigation},
  volume={113 12},
  • Bert L Semler
  • Published 2004 in The Journal of clinical investigation
The genetic basis for the attenuation of polio vaccines has been known since the 1980s. Changes in the internal ribosome entry site, within the 5' noncoding region of genomic RNAs, were presumed to reduce translation in certain target organs, leading to the conclusion that attenuation is mediated at the level of translation. A report in this issue of the JCI reveals that poliovirus tropism is, in part, determined after internal ribosome entry.