Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2.

@article{Coyne2007PoliovirusEI,
  title={Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2.},
  author={Carolyn B Coyne and Kwang Sei Kim and Jeffrey M. Bergelson},
  journal={The EMBO journal},
  year={2007},
  volume={26 17},
  pages={4016-28}
}
Viruses use specific receptor molecules to bind selectively to target cells. Receptors have often been considered as mere docking sites, but they may also possess intrinsic signaling capacities that serve to prime the cell for entry and infection. Poliovirus (PV) initiates infection by binding to the PV receptor (PVR) and causes paralytic poliomyelitis by replicating within motor neurons of the brain and spinal cord. We have examined the process by which PV enters cultured human brain… CONTINUE READING
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