Poliovirus antigenic hybrids simultaneously expressing antigenic determinants from all three serotypes.

@article{Murdin1992PoliovirusAH,
  title={Poliovirus antigenic hybrids simultaneously expressing antigenic determinants from all three serotypes.},
  author={Andrew D. Murdin and Hui Hui Lu and Mar{\'i}a Gabriela Murray and Eckard J Wimmer},
  journal={The Journal of general virology},
  year={1992},
  volume={73 ( Pt 3)},
  pages={
          607-11
        }
}
We have constructed six hybrid polioviruses (PVs) modified to express PV type 2 and type 3 antigenic determinants on a PV type 1 (Mahoney) capsid. The hybrids were modified in neutralizing antigenic site (NAg) I and/or NAgII. They were viable, but impaired for growth in comparison to PV1 (Mahoney). Some hybrids modified to express type 2 and type 3 NAgI determinants simultaneously displayed some type 2 but no type 3 antigenicity (in addition to type 1 antigenicity associated with other… CONTINUE READING

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