Polihexanide: A Safe and Highly Effective Biocide

@article{Kaehn2010PolihexanideAS,
  title={Polihexanide: A Safe and Highly Effective Biocide},
  author={Kurt Kaehn},
  journal={Skin Pharmacology and Physiology},
  year={2010},
  volume={23},
  pages={7 - 16}
}
  • K. Kaehn
  • Published 1 September 2010
  • Biology, Medicine
  • Skin Pharmacology and Physiology
Polihexanide is a broad-spectrum antiseptic with excellent tolerance and a low-risk profile. The physicochemical action on the bacterial envelope prevents or impedes the development of resistant bacterial strains. Thus, polihexanide is particularly suitable and useful in the struggle against multidrug-resistant bacteria. The ecological database is still incomplete. There is some evidence that biodegradation requires adsorption to inert surfaces and that only a small number of bacterial species… 
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Bactericidal effects of polyhexamethylene biguanide against intracellular Staphylococcus aureus EMRSA-15 and USA 300.
TLDR
Investigation of the antibacterial activities of six topically used antimicrobials and a cationic polymer, polyhexamethylene biguanide (PHMB), against intracellular MSSA strain RN4420 and MRSA strains EMRSA-15 and USA 300 finds that PHMB kills intrACEllular MRSA via direct interaction with pathogens inside keratinocytes and host cell entry is dynamin dependent.
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References

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In-vitro activity of polyhexamethylene biguanide (PHMB) against fungal isolates associated with infective keratitis.
TLDR
Polyhexamethylene biguanide (PHMB), which is currently used as an environmental biocide and contact lens disinfectant, has been shown to have excellent in-vitro activity against a broad range of fungal pathogens and to be effective and well tolerated at concentrations of 200 mg/L when used as treatment of patients with keratitis.
The effect of a polyhexamethylene biguanide mouthrinse compared with a triclosan rinse and a chlorhexidine rinse on bacterial counts and 4-day plaque re-growth.
TLDR
Consistent with previous studies, a PHMB mouthrinse was shown to inhibit plaque re-growth and to reduce oral bacterial counts, indicating that PHMB could be an alternative to established mouthrinses in preventive applications.
Microbial degradation of the biocide polyhexamethylene biguanide: isolation and characterization of enrichment consortia and determination of degradation by measurement of stable isotope incorporation into DNA
Aims:  To isolate micro‐organisms capable of utilizing polyhexamethylene biguanide (PHMB) as a sole source of nitrogen, and to demonstrate biodegradation of the biocide.
The effect of a polyhexamethylene biguanide mouthrinse compared to an essential oil rinse and a chlorhexidine rinse on bacterial counts and 4-day plaque regrowth.
TLDR
Consistent with a previous study, a PHMB mouthrinse was shown to inhibit plaque recolonisation and to reduce oral bacterial counts, indicating that PHMB may find applications in the prevention of plaque-associated diseases.
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TLDR
Involvement of specific membrane structures of sphingomonads such as unusual sphingolipids is suggested for membrane transport of xenobiotic compounds, especially hydrophobic materials.
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TLDR
Fluorescence-based biochemical assays demonstrated that the ostricacins bound lipopolysaccharides and disrupted both outer and cytoplasmic membrane integrity, indicating promising possibilities for the peptides to be used in the development of therapeutic and topical products.
The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide.
TLDR
The results showed that a wide range of genes was altered in transcriptional activity and that all of the corresponding knockout strains subsequently challenged with biocide were altered in tolerance, suggesting a novel dimension in the mechanism of action of PHMB based on its interaction with nucleic acids.
Synergism within polyhexamethylene biguanide biocide formulations.
TLDR
Combinations of various molecular weight fractions of PHMB were evaluated against filter-washed cells and revealed a profound synergy between extremes of polymer length.
Mechanisms of action of ostrich β‐defensins against Escherichia coli
TLDR
Fluorescence-based biochemical assays demonstrated that the ostricacins bound lipopolysaccharides and disrupted both outer and cytoplasmic membrane integrity, indicating promising possibilities for the peptides to be used in the development of therapeutic and topical products.
The impact of topical antiseptics on skin microcirculation.
TLDR
The findings show that the alcoholic solutions are most aggressive to skin microcirculation.
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