Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts.

@article{Menndez1994PolicosanolIC,
  title={Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts.},
  author={Roberto Men{\'e}ndez and Sarojani Fernandez and Alfonso Del R{\'i}o and Rosa Mar{\'i}a Gonz{\'a}lez and V M Fraga and Ana Mar{\'i}a Amor and R M M{\'a}s},
  journal={Biological research},
  year={1994},
  volume={27 3-4},
  pages={199-203}
}
Policosanol is a mixture of aliphatic primary alcohols isolated and purified from sugar cane wax, that induces cholesterol-lowering effects in experimental models and human beings. When human lung fibroblasts were incubated with policosanol for 48 hours prior to the experiment, a dose dependent inhibition of 14C-acetate incorporation into total cholesterol was observed, whereas labeled mevalonate incorporation was not inhibited. Even when cholesterol synthesis was not strongly inhibited, low… CONTINUE READING