Pole test is a useful method for evaluating the mouse movement disorder caused by striatal dopamine depletion.

@article{Matsuura1997PoleTI,
  title={Pole test is a useful method for evaluating the mouse movement disorder caused by striatal dopamine depletion.},
  author={Kuniomi Matsuura and Hideaki Kabuto and Hiroshi Makino and Norio Ogawa},
  journal={Journal of neuroscience methods},
  year={1997},
  volume={73 1},
  pages={45-8}
}
We evaluated the behavioral recovery of mice with 6-hydroxydopamine (6-OHDA)-induced lesions using a pole test. T(LA) (locomotor activity time) 1, 2, and 3 days after intracerebroventricular 6-OHDA injection (T(LA)(1-3D)) was correlated significantly with the levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) in the striatum 7 days after the injection of 6-OHDA, but 5-hydroxyindoleacetic acid (5-HIAA) and serotonin (5-HT) had no correlation with T(LA)(1-3D… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 102 extracted citations

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2013
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…