Polarized trafficking of the sorting receptor SorLA in neurons and MDCK cells.

@article{Klinger2016PolarizedTO,
  title={Polarized trafficking of the sorting receptor SorLA in neurons and MDCK cells.},
  author={Stine C. Klinger and Anne H{\o}jland and Shweta Jain and Mads Kjolby and Peder Madsen and Anna Dorst Svendsen and Gunilla Olivecrona and Juan S Bonifacino and Morten S Nielsen},
  journal={The FEBS journal},
  year={2016},
  volume={283 13},
  pages={
          2476-93
        }
}
The sorting receptor SorLA is highly expressed in neurons and is also found in other polarized cells. The receptor has been reported to participate in the trafficking of several ligands, some of which are linked to human diseases, including the amyloid precursor protein, TrkB, and Lipoprotein Lipase (LpL). Despite this, only the trafficking in nonpolarized cells has been described so far. Due to the many differences between polarized and nonpolarized cells, we examined the localization and… CONTINUE READING
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