Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins.

@article{Kim1997PolarizedSB,
  title={Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins.},
  author={Stuart K. Kim},
  journal={Current opinion in cell biology},
  year={1997},
  volume={9 6},
  pages={853-9}
}
Extracellular signals are normally presented to one surface of epithelial cells and to one end of neurons, and so neuronal and epithelial cell signaling is inherently polarized. Another aspect of signaling polarity is that receptors are often asymmetrically distributed on the surfaces of polarized cells. Recent evidence from studies of Caenorhabditis elegans shows that signaling polarity plays an important role in development. The underlying mesoderm induces the overlying ectoderm to form the… CONTINUE READING