Polarized distribution of ion channels within microdomains of the axon initial segment.

@article{Wart2007PolarizedDO,
  title={Polarized distribution of ion channels within microdomains of the axon initial segment.},
  author={Audra Van Wart and James S Trimmer and Gary Matthews},
  journal={The Journal of comparative neurology},
  year={2007},
  volume={500 2},
  pages={339-52}
}
Voltage-gated sodium (Na(v)) channels accumulate at the axon initial segment (IS), where their high density supports spike initiation. Maintenance of this high density of Na(v) channels involves a macromolecular complex that includes the cytoskeletal linker protein ankyrin-G, the only protein known to bind Na(v) channels and localize them at the IS. We found previously that Na(v)1.6 is the predominant Na(v) channel isoform at IS of adult rodent retinal ganglion cells. However, here we report… CONTINUE READING
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