Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells.

@article{Hong2011PolarizedBD,
  title={Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells.},
  author={Jeong Hee Hong and Qin Li and Min Seuk Kim and Dong Min Shin and Stefan Feske and Lutz Birnbaumer and Kwong Tai Cheng and Indu S Ambudkar and Shmuel Muallem},
  journal={Traffic},
  year={2011},
  volume={12 2},
  pages={
          232-45
        }
}
Polarized Ca(2+) signals in secretory epithelial cells are determined by compartmentalized localization of Ca(2+) signaling proteins at the apical pole. Recently the ER Ca(2+) sensor STIM1 (stromal interaction molecule 1) and the Orai channels were shown to play a critical role in store-dependent Ca(2+) influx. STIM1 also gates the transient receptor potential-canonical (TRPC) channels. Here, we asked how cell stimulation affects the localization, recruitment and function of the native proteins… CONTINUE READING
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