Polarized CD163+ tumor-associated macrophages are associated with increased angiogenesis and CXCL12 expression in gastric cancer.

@article{Park2015PolarizedCT,
  title={Polarized CD163+ tumor-associated macrophages are associated with increased angiogenesis and CXCL12 expression in gastric cancer.},
  author={Jae-Young Park and Ji-youn Sung and Juhie Lee and Yong-Koo Park and Youn Wha Kim and Gou Young Kim and Kyu Yeoun Won and Sung-Jig Lim},
  journal={Clinics and research in hepatology and gastroenterology},
  year={2015},
  volume={40 3},
  pages={
          357-365
        }
}
PURPOSE Tumor-associated macrophages (TAMs) play a significant role in tumor progression and angiogenesis. However, the prognostic value of TAMs in different histologic locations of gastric cancer (GC) is still unknown. We evaluated the distribution of TAMs in different histologic locations to investigate its importance in predicting prognosis and the relationship with angiogenesis and CXCL12 expression in GC. METHODS AND MATERIALS The distribution of TAMs and microvessel density (MVD) in 113… CONTINUE READING
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